BIG S H ( ) S '{EAR ′ p 0 に 5 a Mad, Mad, Bad, Bad WorId HOPE FLOATS po 0 de Galinhas, B 「 az ⅱ一丁 h 凾ま「 us swept the Americas in 2016 , causing a serious birth defect called microcephaly. Here, a mother plays with her 5-month-oId daughter, whO was bO 「 n with he defect. Every year has its share ofwar and bloodshed, chaos and tumult. But few in recent memory rival 2016. Sure, there were modest victo- ries, briefmoments oftriumph (Standing Rock). But most us will remember thiS year for its outbursts Of ⅵ 0- lence, itS paroxysms Of terror—and, ofcourse, the shock ofwatching the old order crumble. lt wasn't just Brexit, Trump, fake news and police shootings. lt was the persistence Of ISIS, and the way our nightclubs were turned intO crime scenes. On our SOCial media feeds, we watched migrants drown, the residents ofAleppo starve and a diplomat bleed out on the floor Ofan art gallery in Turkey. And Prince iS dead. Welcome tO 2017. G T A GRIP Detroit 旧 March, GOP residential candidate DonaId Trump displays his digits after a de- bate 「ⅳ mocked his s all hands. Tru p will take 」 anuary 20 , 201

巴川出新Ⅲ 一 0 ロ 8 advances and societal views evolve, the clinical use ofgermline [embryo] editing should be revis- ited on a regular basis. The scientists have reason tO be a11XIOllS.• Some oftheir brethren have raced ahead already. ln April 2015 , researchers in Guangzhou, China, announced they had conducted a CRISPR gene-modification experiment on defective DESPITE Niakan S momentous VICtory, it remams human embryos, t0 edit the gene responsible for illegal in the し K. t0 implant genetically modified beta-thalassaemia, a potentially fatal b100d dis- embryos int0 a womb for the purpose 0f giving order. lt was a resounding failure, because the birth. That ensures that modified genes are not passed ontO future generations; Niakan's lab must CRISPR method accidentally edited the wrong genes, which ended 叩 irreversibly scrambling destroy every embryo after the seven-day mark. the embryo's DNA. Although Niakan insists this research has no That research sparked a hot global debate bearing on actual babies (for now), many in the scientific community are considering the possibil- in the academic fraternity about whether tO ity that a modified embryo could result in a living declare a moratorium on embryo modification child. ln December 2015 , several hundred scien- until ethics laws and regulations could catch up tists from around the world gathe red in Washing- With science. ln response, scientists fror the ton, D. C. , for the first ever international summit United States, Britain and China at the Wash- on gene editing. At its close, the event chairman, mgton summit called for a temporary freeze on Nobel Prize-winning biologist David BaItimore altering human embryos destined for birth, call- ing it "irresponsible" and potentially dangerous ・ of the CaIifornia lnstitute of Technology, issued its conclusions, sayng, As scientific knowledge The quick decision tO cooperate internation- B A B Y S T E P S NEWSWEEK 34 01 / 13 / 2017

も物 宿ゞも 十 BLACK DEATH: A chapel made from bones 0f people whO perished from the plague during the MiddIe Ages. The disease iS enough Of a current threat that scien- tists are trying tO develop a vaccine. 朝物一 affected countries are Madagascar, BO H THE U. S. AND THE the Democratic Republic Of Congo and Peru. According t0 the CDC, the SO ET UNI ON CONSI DERED U. S. sees an average Of seven human SP EADING PLAGUE plague cases each year. ln 2015 , there were 16 cases,including t 、Ⅳ 0 teenagers BA TERIA AS AN AEROSOL WhO visited Yosemite National Park in DU ING THE COLD WAR. California. Four ofthe 16 were fatal. As ofearly November, only four cases had been reported this year and all patients recovered, according tO the CDC. Vaccines for the plague exist, but they have 11 れ 1 咀 une response in the animals tested. The team S01 れ e senous flaws. One that was made With gave れ AJO doses Of each vaccme tO mice and then challenge d the animals ' immunity W1th highly dead bacteria and is approved by the U. S. Food and Drug Administration is no longer manu- virulent plague strains. The mice were protected factured. lt protected against only the bubonic up tO four months later. TWO Of the mutant strains plague, not the more dangerous pneumonic were alSO successfully tested in rats. plague. Another vaccine iS used in areas where Chopra also has a plague vaccine in the works the bacteria are endemic, but it's not approved that uses the bacteria s antigens (substances that trigger an immune response) rather than by the FDA because 0f its high likelihood to whOle bacteria. ln tests in nonhuman primates, cause severe side effects, such as fever and it was shown t0 be highly protective. headaches. The vaccines Chopra discussed in Everybody's immune system is different, SO Na 尾 protect against the pneumonic plague some people could be protected and some may and don't cause side effects. not be," Chopra says. His goal is tO "have in our TO prepare the candidate vaccines, the pipeline several vaccme candidates. " ロ researchers deleted three genes each Of three candidate strains Of plague in order tO we aken the This story was written exclusively for Newsweek by bacteria, but not kill them. The strains could no Kaiser Health News, part Of the nonpartisan Henry 」 . longer cause disease, but they generated a robust Kaiser FamiIy Foundation. NEWSWEEK 51 01 / 13 / 2017

she passed out. "Since then l've been having nightmares," the 52-year-01d says. "I am troubled in my mind. The massacre in the village of Mayi-Moya, about 30 miles north ofthe town of Beni, went largely unreported; in the region around Beni, which is located in the conflict-wracked prov- ince Of North Kivu, little was remarkable about the assault. Since late 2014 , the area has suf- fered a series of attacks, largely attributed to a Ugandan rebel group known as the Allied Democratic Forces (ADF). The violence has le 代 nearly 700 civilians dead, according to Human Rights Watch, but local sources put the figure considerably higher. Eastern DRC has been riven by conflict since 1994 , when a massive influx Of Hutu refugees fled across the border from neighboring Rwanda, aring pe rse cution by the new Tutsi administra- tion in that country. Among them were many Of The people 0f Beni are also angry and afraid. When the government donated cofflns to the families of six people hacked t0 death in early November, irate youths burned them in protest against what they believe is the government's failure tO protect them. After each new massa- cre, people gather at the crime scene and the morgue tO check that their loved ones are not among the dead. ln August, a dozen people were crushed t0 death in a panicked stampede after a drunken off-duty soldier fired four rounds into ER EACH NEW SACRE, PEOPLE GATHER P A G E 0 N E / C 0 N G 0 the g ど〃 0 da かお accused ofparticipat- ing in the killing 0f hundreds of thou- sands ofTutsis and moderate Hutus in the spring 0f1994 ・ TWO years later, Rwanda invaded, attacking the refugee camps that had become the temporary homes for Hutu militia groups. The Rwandan forces also toppled Congo's infamously cor- rupt dictator, M0butu Sese SekO. The militias never entirely dis- banded, however, and the next decade saw a spiral Of messy conflicts that drew ln nine African states and myr- iad rebel groups. The war was fueled AF AT THE CRIME SCENE AND THE MORGUE TO CHECK TH T THEIR LOVED ONES AR 十 A MOTHER'S PAIN: Kambere Kahendo sits in the home of a friend ⅲ Beni. August, rebels operating in the northeast of the DRC killed seven of her children. by the region s immense natural riches, which include gold, diamonds, tin, timber and coltan, a mlneral essential tO the manufacture Of smart- phones and Other consumer electronics. By 2008 , the lnternational Rescue Committee esti- mated that the conflict had cost about 5.4 million lives, mostly from disease and malnutrition. ln late 2013 , the defeat ofthe M23 movement, a maJ0r Tutsi-dominated rebel group, raised hopes that the cycle of violence could be coming to an end. Hopes were boosted by the creation of a Force lnterventlon Brigade within the long-run- ning し N. peacekeeping force MONUSCO, with a mandate tO aggressively take on armed groups ・ A series ofoffensives in the first half 0f 2014 succeeded in splintering the group, but three years on, With the massacres in Beni continu- ing unabated, locals are increasingly frustrated about the inability of both the army and MON- USCO to control the violence. The ADF, they point out, is currently thought tO number only a few hundred fighters. NOT AMONG THE DEAD. the air. Later that month, rioting broke out after 50 people were killed during a massacre in the Rwangoma suburb Of the town. "This [ADFI conflict has been going on since 1996 , but this is the worst it's ever been, ” says Kasereka Vivuya, a secondary schOOl teacher whose aunt and uncle were kidnapped during a raid in 2013 and have not been seen smce. The government blames the attacks almost exclusively on the ADF, an lslamist-inspired group whose original goal was t0 topple the government 0f neighboring Uganda and replace it with an lsla- mist one. ln the face Of military pressure in their home country, the rebels quickly established the mountainous border region between the DRC and Uganda as their base, from which they carried out low-level attacks ⅲ both countries. Analysts say that the ir actions have shown little if any adher- ence tO their professed religious goals and that a range Of local and regional interests are dnving the recent surge ln violence. A report published earlier this year by the NEWSWEEK 21 01 / 13 / 2017

2 0 1 7 A C U LT U R A L G U ー D E 10 PAGES OF CINEMA, TELEVISION, FOOD, MUSIC, BOOKS, SPORT, TRAVEL, ART AND DESIGN TO LOOK FORWARD TO IN 2017 ・をを第 CINEMA A Big Year 応 r … Chrrstopher N01an THE FEVERED anticipation German plane solely in order that surrounds the release Of tO crash it. any new Christopher N01an If movies are, as welles once said, the "biggest movie—the secrecy! the leaks!—is almost as delicious electnc train set any boy eve r had," then N01an is standing as ル 4 なん g a new Christo- pher NOlan mOV1e. in the middle of it, we anng the dnver's hat. The 46-year- ln late 2015 , reports began tO surface that he and his old director is at roughly the brother Jonathan had been same high point in hiS career spotted scouting locations as Stephen Spielbe rg when he made S 襯ビバ廱立 and northern France for a film based on Operation James Cameron When he Dynamo. This was the Brit- made T 耘 4 ⅲ c. D リれたかた marks ish military effort that saved the first foray into the histor- the lives 0f 330 , 000 Allied ical record from a filmmaker soldiers WhO were evacuated whose unbroken string ofhits, from the French town of 仕 omn イの 7 肥〃知 tO 万ル 2 0 〃 , V1a Dunkirk, an event that Win- The Da 液 K れら have turned ston Churchill later called a him into his own blockbuster miracle ofdeliverance. brand with a devoted fan Slowly, news leaked of following—and a history of a cast that included Tom paymg the price for it at the starts with the sound Of a tick- Yet despite earnlng a Hardy, Cillian Murphy, Ken- Oscars. After ー〃 c ビ 2 0 〃 was reported $ 20 million salary ing clock and a sh0t 0f a wave shut out in 201 も such was the neth Branagh, Mark Rylance for the film, along with a 20 foaming up a beach. The tick- and One Direction member online furor that the next year percent take 0f the profits, ing gets faster; troops appear' the academy widened its best first as distant specks on the Harry StyIes. Then came the director is shouldering a reports that NOlan was film- picture net tO include a POSSI- certain amount Of risk. can horizon, then crowded ontO ing on a real-life naval ship, ble 10 moues, ⅲ the hopes of he wring box-offce success a stone harbor wall. The tick- a French T47 class destroyer c atching the odd blockbuste r from a historic al rout? ing gets faster. The whining brought in from Brittany, and hit. D Ⅷた減 could well be TO judge by an early trailer, sound of a bomber overhead had spent $ 5 million buying a 2017 ' s big fish. if anyone can, it's NOlan. lt draws the men S gazes up, one NEWSWEEK 54 01 / 13 / 2017

P A G E 0 N E / N 0 R T H K 0 R E A DE し USIONA し 0 ORDER The White House is warning Donald Trump that North Korea is America's biggest foreign policy problem, which is absurd AS PRESIDENT Barack Obama prepares tO leave offce, consider the world he has left us. ln Syria, B ashar al-Assad's regime—backe d by lran and Russia—is finishing a savage bombing campaign t0 retake Aleppo. Tens 0f thousands have been killed, hundreds of thousands have been exiled and an entire generation Of Sunni Arabs in the country has been embittered. An administration whose members once touted a doctrine called the "responsibility tO protect, now silently watches a genocide, evidently believ- ing that U. S. intervention would somehow make the situation worse, and probably threaten what this president views as his prized foreign policy trophy: an agreement with lran that purportedly restrains that regime S nuclear weapons program, at least for a while. The lslamic State militant group (ISIS), mean- while, recaptured the Syrian city of PaImyra— which had fallen months ago—and, oh yes, Al-Qaeda has never had 1 ore Of a presence ln more countries than it does tOday, despite the administration's claims tO the contrary. Then there's Russia. ln addition to restoring its influence in the Middle East, Moscow has lopped 0 代 Crimea in Ukraine, and the CounciI on For- eign Relations now posits that the possibility 0f a NATO-Russia confrontation is as high as it has been since the end ofthe CoId War. And finally, on December 15 , Beijing announced it has deploye d powerful anti-aircraft and anti-missile systems tO all seven Of its new artificial islands in the Spratly archip elago. Then China seized a し S. submersible drone operatmg in lnternational waters in the South China S e a, only tO agree tO return it tWO days later. Given that litany of debacles abroad, it might surprise you tO learn the Obama administration is telling the Trump crowd that the biggest for- eign policy issue the incoming president will face is North Korea. Where to begin? Let's start with how this administration's policy in dealing with pyong- yang has been called "strategic patience. ' As The Ⅳ 4 〃 & 匆れ記 put it recently, Obama has refused tO engage his administration in high-level negotiations with North Korea, wait- ing for its leader, Kim Jong Un, t0 show he is committed tO abandoning his nuclear arsenal. l've only been tO North Korea twice, but I am certain Kim is never going tO voluntarily abandon his nuclear arsenal.Why? Because it's all he's got. lt's the only thing standing between him and a job as a body double for the guy who plays him in the sequel t0 T んど加ル . Kim, in his own way, kept telling us this, too—with a series Of tests Of his nukes and ballistic missiles. The adminis- tration begged, pleaded and cajoled China to BY BILL POWELL NEWSWEEK 24 01 / 13 / 2017