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newest HEALTH Ca れ ce ′ 貨 COMBINES THE POWER 0 ド GENETICS AND THE IMMUNE SYSTEM, AND IT'S SAVING LIVES m ま′ 00 ー e Cure BY ALICE PARK PHOTOGRAPH BY BRENT HUMPHREYS FOR TIME

Time Off PopChart Rihanna announced a five- year partnership with a bike- sharingfirm tO help provide better access tO education for girls in MaIawi. DespicabIe Me became the top-grossing animated-film franchise ever, surpassingShrek, with the latest Minions movie pushingthe tOtaI global box Office over $ 3.5 billion. 」 apan's Biotherapy Development Research Center has reportedly created ice cream that doesn 't melt. 'What l'm not gonna dO is be ashamed of my mistakes. I wanna be a man that learns from them and grows from them. ' —JUSTIN BIEBER, after canceling the remainder of his Purpose World Tour TIME'S WEEKLY TAKE ON TWO months afte r the rocker's death, Chris CorneII's 12- yea 「 da ughter Toni paid tribute tO her dad with a moving rendition Of ・・ HaIlelujah" on GOOd Morning America. 産 く 0 LOVE IT LEAVE IT WHAT POPPED IN CULTURE TLC personality Derick Dillard came under fire What an oxymoron••• a "realityø show which fOllOWS a non-reality. "Transgenderø is a for posting a myth. Genderis not fluid; it' s ordained by transphobic tweet G . about lAmJazz star 」 a Jennings. 引知爪黶な駅物ー 'OW. 第、′の権ー & 第 w 1 し C 用、・一 L ・を物 02 物 0 第・ 1 物′物 0 : ー Game Of Thrones creator George R. R. Martin tweeted that despite getting recognized nearly everywhere he goes, he wasn't recognized in his publisher's office, where security guards demanded to see his 旧 . RI 工 ANNA: DENNIS LEUPOLD; DESPICABLE ME 3 】 UNIVERSAL; SWINEAPPLE ( 2 ) 】 INSTAGRAM; T 工 IS IS US 】 NBC; DILLARD: TWITTER; BIEBER, ICE CREAM, CORNELL. MARTIN, SMIT 工】 GETTY IMAGES 7 ~ 戸 M 、 2 角」 0 加 1 ? 」 aden Smith's cardboard- packaged-water sta rtu p i s suing a vegan- mayonnaise company over a branding dispute. lnstagram's hottest fOOd trend is the "swineapple"—a grilled pineapple stuffed with pork and wrapped in bacon. The NBC drama Us will lose one Of its 11 Emmy nominations, for contemporary costume design, because most Of itS season finale takes place in the 1970S rather than in the past 25 years, as the award's regulations require. レノイ担 50 TIME August 21 , 2017 By Raisa Bruner, Cady Lang and Megan McCluskey

Mi1estones DIED 」 apanese actor Haruo Nakajima, whO portrayed the monster Godzilla in at least 12 movies includingthe 1954 original, at 88. 》 HeIen Alexander, British champion ofwomen's equality whO became the first female president Of the Confederation of British lndustry, at 60. 》 RObe Hardy, British character actor whO played Prime Minister Winston Churchill several times as well as Cornelius Fudge in four Harry POtter movies, at 91. 》 Chantek, an orangutan from Atlanta whO was one Of the first apes tO learn sign language, at 39. 旧 2014 , Chantek starred in PBS's The Ape Ⅳわ 0 Went tO CO 〃 ege. SIGNED A $ 263 million deal with Paris Saint-Germain by Brazilian soccer star Neymar, making him the most expensive playerin the sport's history. IDENTIFIED The remains Of a male 9 / 11 victim, 16 years after the terrorist attack, through the use Of advanced DNA technology that tests bone fragments. RETIRED Usain BOlt A singular sprinter BEFORE ALMOST EVERY BIG race Usain BOlt ran, the crowd hailed the lithe Jamaican as he bounced around the track with a fervor usually reserved for royalty and rock stars. Then, quicker than one of his flashes to the finish, fans shushed before the starting gun, the silence building in electric anticipation Of another gold medal, another world record. With his eight Olympic gold medals, 11 world title s and unfathomable record times—9.58 sec. in the 100 m, 19.19 sec. in the 200 m—Bolt singularly turned his doping- tainted sport intO a feel-good global spectacle. ln his last SOIO race before his retirement, the 100- m final 0 Ⅱ Aug. 5 at the 2017 track-and-field world championships in London, Bolt starte d too slow and finished third. The turn was unexpected for an athlete whO tended tO write storybook endings. But afterward the winner, American Justin Gatlin, bowed to his longtime rival—a recognition that no matter the result ofthis last race, BOlt is the greatest sprinter Of all time. His departure leaves a VOid that will be nearly impossible to 6 Ⅱ . —SEAN GREGORY The Rhinestone Cowboy s も on 面ⅲ 1970 GIen Campbell Country with 0 hidden edge MAYBE IT'S AN ARKANSAS THING. IF IT TOOK THE TOWN of Hope to give us the preternaturally optimistic BiII CIinton, it took the town ofDelight to give us Glen Campbell, who died on Aug. 8 at age 81. The singer, songwriter, television host and, sometimes, cautionary tale, who sold 45 million records and was inducted into the Country Music Hall of Fame in 2005 , had been suffering from AIzheimer's disease, a diagnosis he made public in 2011. Campbell was at the vanguard Of country music's embrace Of more mainstream pop in the 1960S and ' 70S , and with hits like "Rhinestone Cowboy" and "By the Time I Get to Phoenix ” he offered easy, unthreatening listening ⅲ a turbulent time. But that belied his musical history. He played in dive bars ⅲ Albuquerque early in his career and was a key member Of the small corps Of LOS Angeles seSSIOn musicians known as the Wrecking Crew, along with the likes 0f rocker Leon Russell, who died last year. There were, too, Campbell's three broken marriages and his widely publicized battles with alcohol and cocaine. lt was his fourth wife and now widow Kimberley Woollen who, Campbell said, helped him regain both his equilibrium and his grace. He set out on a 151- show farewell tour that ended ⅲ 2012 , and in June released his final album. lt was simply—and bravely—titled A 市 6s. —JEFFREY KLUGER DIED dV—snv 工 9N&03ーN V 「 NV 】 1 コ 08 A1139 、の NH3 」 03d ー N 工 3 」 03 工 0 一 > VCJ 」コく 0 の一トト 39 ー 39N く M3 工 0 】 NO の 3 コョト 63 9

Reviews Time 0 ーをミ、 mother and student whO put her education on h01d tO organize marche S and demonstrations in the wake of Brown's killing. Her daughter Kenna was 6 at the time and tOOk part in the protests with her mother from the start. "I want her tO think for herself, to resist and p articip ate in de mocracy, Farrell says. "That is your right, and that c annot be taken away from you. The most effective images n Whose Streets? are those 0f peaceful protesters holding s igns ー including two girls be aring matching placards emblazoned with pink handprints and the legend DON'T SHOOT— as members oflocal law enforcement and the military hold their weapons at the ready. ()t times during the demonstrations, police used tear gas. ) ln one sequence, police tell nighttime demonstrators tO “ return tO their homes; unaware—and seeming not tO care—that those people are standing ⅲ their own front yards. F01ayan also includes footage ofthe looting and rioting that are part Of this story, an eruption Of anger 'lt wasn't being and frustration that marred registered ⅲ the p rote sts that ought tO have been peaceful. But the movie mainstream media isn't intended tO be a strict as grie f— it was procedural record 0fwh0 being registered as did what, when. lnstead, "They're thugs. "' it's a brash example 0f SABAAH FOLAYAN, in E 〃 e, guerrilla filmmaking— its describing the frustration immediacy and itS energy that led her to make are its stronge st attributes. Whose Streets?, about the Ferguson protests The protests gave a jolt of momentum tO the Black Lives Matter movement, established ⅲ 2013 following the acquittal 0fGeorge Zimmerman ⅲ the killing ofTrayvon Martin. Whose Streets? is part of the middle ofthe story. lt's by no means the end. 0 ドⅧ 0 BLAC K IIVES T を : 丁こ、 、デ第ド MOVIES Activist Brittany Farrell and daughter Ke れれ 0 : these are their streets Whose Streets? is a ragged, bracing protest document By Stephanie Zacharek LITTLE GOOD CAN COME FROM THE TRAGEDY OF MICHAEL Brown. The 18-year-01d unarmed black manwas shot to death in the city ofFerguson, MO. , near St. Louis, on Aug. 9 , 2014 , by white police offlcer Darren Wilson, who fired 12 bullets. After Brown was killed, his body lay ⅲ the street for four hours before being transported tO a morgue. A St. Louis County grandjury declined t0 indict Wilson, and a subsequent Department ofJustice investigation concluded that he did not ViOlate Brown's constitutional rights. But the community knew that a grave wrong had been committed. Citizens gathered in peaceful protest, though in some cases their anger erupted into violence. Sabaah Folayan's documentary Whose Streets?, co-directed by Damon Davis, is a gritty record ofthat time and its aftermath. lt repre sents the spirit Of something more powerful than a bullet, the seed ofsomething good springing from a terrible and unjust event. Whose Streets? is rough around the edges, like a torn photograph whose borders have also been raggedly burned. But that's more a strength than a liability: Folayan makes extensive use Of citizens' cell-phone and video-camera f00tage shot on the fly, much 0f it capturing a community struck with anger and s orrowful shock in the hours and days following the shooting. Folayan als 0 conducts interviews with the people who formed the backbone of the resistance movement that sprang up in Ferguson and quickly captured the attention 0f the country, and 0f the wo rld. Those interviewees include Brittany Farrell, a young 46 TIME August 21 , 2017 ロ

0 esl onstage ⅲ 1972 , the same year he playedfour so 旧 - out shows at Ma 市 so れ Square Garden in New r た夜収 ◆ The roots of that elus ive explanation, however, way. The first phase, on television in the 1950S , he did may lie not in the mechanics oftraditional celebrity things that ⅲ those days people only did in private. but ⅲ the SOCi010 of a force that was always vital lt was like he was saying, 0. K. , you don't have to feel in the lives 0fPresIey's most ardent fans: religion. ln guilty about it. ln the second phase of his career, he death, PresIey has become a quasidivine figure whose added something. ln his concerts, he not only did savior-like appeal comes from his journey from the the movements and motions, by that time commonly ordinary tO the extraordinary. "lt is very common accepted, but he also added spiritual songs at the end. for people tO experience the divine in what can only ln effect he was saying, Not only are your impulses be an inadequate human being," Karen Armstrong, a 0. K. ー now they are blessed. ” scholar ofworld religions, told Harrison for his 1997 Was Leonard Bernstein right? Did the whole ' 60S BBC documentary Elvis 0 れ d the Presl r れ s. "The come from Presley? Surely much 0f it did, and the essential and amazing thing about the spiritual quest 70S t00, and the ' 80S , up t0 our own day. Presley's is that the divine is able to be apprehended at all. So life is a kind 0f American tragedy—a talent 0f epic Of course we think that Elvis is a grossly inadequate proportions cut short by indulgence and app etite ー symbol of the divine, but one could have said the but if his story is personally tragic, it's a story that same ofJesus, after all. He died the death, the very is not yet over. Shawn Klush, a Presley tribute artist common death, Of a disgraced criminal.' wh0 was on HBO's I , will be at Graceland this The trappings of the Presley legacy do echo month for the anniversary 0f the King's death. "I religious ceremonies. HiS tribute artists—or priests, believe Elvis remalns so popular 40 years after his if you will—dress in white costumes, re-enact the death mainly ⅲ part due to the kind ofman he was, Klush says. "people love him, not only for his talent, actions and speak the words of the cultic founder, and make promises. ln the Christian worldview, there but because he was a great, humble, kind man. is salvation, the forgiveness Of sin; in the Presley He loved God. He loved his parents. He loved his country.' And his country loved him—for his voice, ethOS, there is freedom from restraint, afflrmation. "His whOle existence was tO take guilt away from for his spirit and because it saw in him, forbetter and people; ” the psychologist Richard Maddock told for worse, what itwas and what it hoped t0 be. —With Harrison. "He started out thatway and ended up that reporting by ANNA RUMER/WASHINGTON ロ 600K Average number Of yearly visitors to Graceland since it opened tO the public in 1982 く 80 , 000 fans turn out for PresIey's funeral. く PresIey's girlfriend discovers him unresponsive ⅲ a bathroom at Graceland. He is pronounced dead that afternoon. PresIey's health deteriorates. An abuser Of prescription drugs, he suffers om glaucoma, high 000 pressure and otherissues. A 代部 years of growing distance and infidelity on both sides, Elvis and PrisciIIa d ⅳ 02e. AUG. 18 , 1977 AUG. 16 , 1977 1970S OCT. 9 , 1973 41

す U R N ー N G 1 H E B 0 DY ー N 10 A C A N C E R 日 G H す E R A breakthrough new approach, awaiting FDA approval, has the potentialto transform cancer treatment by converting the bOdy's own cells intO cancer-destroying agents. Here's hOW it works: WITH THE USUAL MIX OFANTICIPATION and apprehension, Kaitlyn J0hnson is etting ready tO go t0 her first summer camp. She's looking forward t0 meeting new friends and being able to ride horses, swim and hOSt tea parties. She's alSO a little nervous and a little scared, like any 7-year-01d facing her first sleepaway camp. But the wonder is that Kaitlyn is leaving the house for anything but a medical facility. Diagnosed with leukemia when she was 18 months old, her life has been consumed With cancer treatments, doctors' visits and hospital stays. Acute lymphoblastic leukemia is the most common cancer among young children, accounting for a quarter of all cancer cases in kids, and it has no cure. For about 85 % t0 90 % 0f children, the leukemia can, however, be effectively treated through chemother 叩 y. lfit is not eliminated and comes back, it is, more Often than not, fatal. Rounds of chemotherapy can buy patients time , but as the disease progresses, the periods Of remission get shorter and shorter. "The options for these patients are not very good at all; ” says Dr. Theodore Laetsch, a pediatrician at the University Of Texas Southwestern Medical Center. When Kaitlyn's cancer wasn't con- trolled after three years and round after round of chemotherapy drugs, her doc- tors had little else to 0 飛 r. "They said, 'This did nothing, it didn't touch it,' ” to ChiIdren's HospitaI of PhiIadeIphia says Kaitlyn's mother Mandy, a dental (CHOP), where they stayed in a hotel for assistant from Royce City, Texas. "My eight weeks while Kaitlyn received the stomach just dropped. " Kaitlyn could therapy and recovered. "The thought receive a bone-marrow transplant, but crossed my mind that Kaitlyn might only about half of those procedures are not come home again; ” says Mandy. successful, and there was a good chance "I couldn't tell you how many times I that she would reject the donor cells. If would be ⅲ the bathroom at the hospital, that happened, her chances 0f surviving spending an hour in the shower just Kaitlyn 砒 age 5 , after receiving her were very small. crying, thinking, What are we going t0 ow 〃 genetically modified immune cells ln a calculated gamble, her doctors do if this doesn't help her? ” sugge sted a radical new option : becoming a revolutionary approach tO cancer But it did. After receiving the therapy a test subject in a trial Ofan experimental treatment that uses a series Of precision in 2015 , the cancer cells in Kaitlyn's body therapy that would, for the first time, use strikes tO dis integrate cancer from within melted away. Test after test, including gene therapy tO train a patient's immune the body itself. Joining the trial was risky, one that picks up one cancer cell in a system tO recognize and destroy their since Other attempts tO activate the million, still can't detect any malignant cancer in the same way it dispatches immune system hadn't really worked in cells lurking in KaitIyn's blood. What ま bacteria and viruses. The strategy is the the past. Mandy, her husband James and saved Kaitlyn was an infusion Of her late st develop me nt in immunotherapy, Kaitlyn traveled from their home ⅲ Texas own immune cells that were genetically 30 TIME August 21 , 2017 Cancer- cell dea TOXins Cancer ce 〃 0 The CAR T-cell rece ptors recogn ize unique proteins on the cancer cells. They latch ontO the proteins, triggering the T cell tO destroy the cancer cell Cancer protein T ce ″

WORLD As Maduro tightens his grip on Venezuela, an insurgency stirs By loan GriIIO BEFORE DAWN BROKE IN VENEZUELA'S colonial city 0fValencia on Aug. 6 , a convoy 0f SUVs pulled up t0 a nearby army base and a gaggle 0f men in green fatigues stormed out, clutching rifles. After a bloody exchange ofgunfire, a number Of men escaped with grenade launchers and 93 Kalashnikovs. While military helicopters searched in vain for the assailants, a video swept the lnte rnet showing a former army c aptain claiming credit for the raid "tO save the country from tOtal destruction. The assault marked a troubling escalation from protests that have convulsed the South American nation since April, as President Nicolås Maduro creeps closer tO outright dictatorship. For months, a section ofdemonstrators have faced off against police and soldiers with rocks, Molotov cocktails and cardboard shields ⅲ clashes that have COSt more than 120 lives. They have also dodged the bullets ofparamilitary groups wh0 claim loyalty t0 the socialist ViSion ofN"laduro's predecessor and mentor, Hugo Chåvez. This latest stage ofthe crisis was sparked by the July 30 election Of a so-called Constituent Assembly, with sweeping powers tO rewrite the constitution. Oppo ne nts decried a fraudulent ballot, but many still seem committed tO pursuing justice at the ballot box ⅲ governorship elections at the end Ofthe year—a move some protesters see as a betrayal after SO many have died on the street. NOW, after the attack on the army base, calls for insurrection are grow- ing louder. Oscar Perez, the rogue po- lice inspector whO has been on the run since he reportedly piloted a helicopter that launched a grenade at the Supreme 0 Protests in Venezuela, like this clash with the れ 0 霞 0 れ 0 ー guard in eastern Caracas 0 れ April 26 , steadily intensified ahead 可市 e い 30 vote PHOTOGRAPHS BY TIME For more ofour bestphotography, visit time.com/lightbox 11

3 0 物。第 = を第敷三当を気 ツ , を第ニ iS a weakened immune system; because meticulously SO that we develop this in the treatment wipes out a category of the right way. ” his immune cells—the ones that turned For now, CAR T cells are expensive— cancerous —he returns tO the University some analysts estimate that each patient's ofpennsylvania every seven weekS for an batch of cells would cost hundreds of infus ion Of immunoglobulins tO protect thousands of dollars—because they him from pneumonia and colds. Olson, require a bespoke production process. tOO, is still cancer-free. If approved, Novartis, which licensed WhiIe the number ofpeople who have the technology from the University of received CAR T cell therapy is still small, Pennsylvania, will provide the therapy the majority are in remission. That'S in about 35 cancer centers in the U. S. by especially encouraging for children, the end ofthe year. Other companies are whose lives are permanently disrupted already workmg toward universal T cells Ludwig with his prized 必 by the repeated cycles oftreatments that that could be created for off-the-shelfuse above, d in 2010 receiving the currently are their only option. "lt's a revolutionary CAR T cell 市 era 〃ツ in any patient with cancer. "This is just chance for these kids to have a normal the beginning, ' s ays June. life and a normal childhood that doesn't advanced—perhaps as a replacement for Since Ludwig's cancer has been in involve constant infusions, transfusions, or in combination With Other treatments. remission, he and his wife have packed infections and being away from their The severe immune reaction triggered their RV and taken the vacations they home, family and school,: ” says Dr. Gwen by the therapy remains a big concern. missed While he was a slave tO hiS cancer Nichols, chief medical offlcer of the While it can be monitored in the hospital and chemotherapy schedule. This year, Leukemia and Lymphoma Society. and managed with steroids or antibodies they 're visiting Mount Rushmore , Grand The hope is that while CAR T cell that fight inflammation, there have been Teton National Park and Yellowstone ther 叩 y will at first be reserved for people deaths in other trials involving CAR NationaI Park before taking their who have failed to respond to 砠 standard T cells. One drug company put one of granddaughter t0 Disney World in the を treatments, eventually they won't have its studies on hOld due tO the toxic side fall. "When they told me I was cancer- t0 wait that long. As doctors learn from effects. "I am excited by CAR T therapy, free, it was just like someone said, 'You pioneers like Kaitlyn, Ludwig and but l'm also worried that some people won the lottery,' ” he says. "lf somebody Olson, they will have more confidence might get tOO excited,: ” says the American else with this disease has the chance tO 箋 in pushing the therapy earlier, when Cancer Society's Brawley. "lt's important walk in my shoes and live past it, that patients are stronger and the cancer is less that we proceed slowly and d0 this would be the greatest gift for me. ' 33 物ー第マ

引 00d - cancer cells T cells—which can seek and destroy cancer cells—are extracted from a patient's bIOOd ② 0 T cell antigen chimeric produce modified to genetically are the T cells ②旧 the lab, DNA ー cell T ce[ls 3 The CAR T cells are grown in ね e numbers in the lab and are infused back intO the patient ceptO (CARs) that make them better cancer fighte rs receptor antigen Chimeric modified to destroy her leukemia. "You take someone whO essentially has no possibility for a cure—almost every single one Of these patients dies—and with [this] therapy, 90 % go into remission,' says Dr. David Porter, director of blood and bone-marrow transplantation at the University of PennsyIvania. Such radical immune-based approaches were launched in 2011 with the success Of intravenous drugs that loosen the brakes on the immune SYStem SO it can see cancer cell s and de stroy them with the s ame vigor with which they attack bacteria and viruses. Now, with the genetically engineered immune cells known as chimeric antigen receptor (CAR) T cells that were used ⅲ Kaitlyn's study, doctors are crippling cancer in more precise and targeted ways than surgery, chemotherapy and radiation ever could. While the first cancer immunotherapies were broadly aimed at any cancer, experts are now repurposing the immune system intO a personalized precision treatment that can not only recognize but also eliminate the cancer cells unique tO e ach individual patient. What makes immune-based therapies like CAR T cell therapy so promising— and SO powerful—is that they are a living drug churned out by the p atients themselves. The treatment isn't a pill or a liquid that has to be taken regularly, but a one-hit wonder that, when given a single time, trains the bOdy tO keep on treating, ideally for a lifetime. "This therapy is utterly transformative for this kind of leukemia and also lym- phoma; ” says Stephan Grupp, director 0f the cancer immunotherapy program at CHOP and one of the lead doctors treat- ing patients in the study in which Kaitlyn participated. Eager to bring this groundbreaking option tO more patients , including those With Other types Of cancers, an advisory panel for the F00d and Drug Administra- tion voted unanimously in July to move the ther 叩 y beyond the testing phase, during which several hundred people Often does, and it iS expected tO announce obligated to follow the panel's advice, it ments have failed. While the FDA isn't with certain leukemias if all other treat- become a standard ther 叩 y for children have been able to take advantage ofit, to 31 Trial after trial failed as reinfusions of cancer and battled skin cancer himself. cancer, having lost his first wife tO ovarian familiar with the devastating effects Of ofthe U. S. NavaI Academy, June is all too wh0 pioneered the therapy. A graduate Abramson Cancer Center and the scientist at the University Of Pennsylvania's 0f the Center for CeIIuIar lmmunotherapy the research,: ” says Dr. CarlJune, director "Only a handful ofpeople were doing its own cells. and the immune system is loath tO target cells that mutate and grow out ofcontrol, the body, cancer cells start out as healthy and viruses that are distinctly foreign tO ing. Unlike infection-causing bacteria the practical reality had proved daunt- cancer has been around for a long time, ofusing the body's immune cells against ever, almost didn't h 叩 pen. WhiIe the idea THIS REVOLUTIONARY THERAPY, hOW- in the U. S. , as well as untold suffering. currently spent each year on cancer care cant drop ⅲ the more than $ 120 billion treating them, would result in a signifi- patients. Curing cancers, rather than may even lead tO a cure for some ofthese tO e ntertain the ide a that this living drug are even cautiously allowing themselves benefit from this novel approach. They hundreds of trials to see if they, too, will diagnosed ⅲ Senator JOhn McCain—in sarcoma and brain, including the kind breast, prostate, pancreatic, ovarian, ing tO enroll people with Other cancers— Across the country, doctors are rac- itS decision in a matter ofweeks.