らイ EVERY LAST " CHILD DESERVES に ~ A FUTURE Save the Children Meet 5- year• -0 旧 Amena. Seeing her safe inside 0 hospital, リ ou wouldn't know that she's 0 child refugee from Syria, recently rescued at sea from certain death. At save the Children, we dO whatever it takes ー every da リ and in times Of crisis ー t0 ensure children likeAmena grow up healthy, learning and safe. NO matter wh0 they are or where they're born. Because every child deserves 0 future. Every st child. SavetheChiIdren.org/Amena WatCh Amena's dramatic rescue and recovery. *ChiId's name changed for protection. ◎ 2017 , Save the Children. AII rights reserved. Ph0to: Louis Leeson.

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0 The View Time Off The Features 2 ー Conversation 4 ー For the Record 加 the bathroom What tO watch, read, ロ Call Of Duty 0 工ん s suite at the see and dO Warwick Hotel, Newly installed as white House EIvis PresIey checks 4 引 Aubrey PIaza chiefofstaff, retired GeneraIJohn hiS hair in 0 mirror steps out inlngrid as he preparesfor KeIIy is bringing a dose ofmilitary Goes West hiS appearance 0 れ discipline t0 the West Wing CBS's Stage Show 46 ー A new ByMichaelDuffY22 0 れ M ch17, , 1958 , documentary on the ⅲグれ hat れ Fergusonprotests Photo 叩 h A Cancer Breakthrough 4 引 TV: New family A revolutionary gene therapy can Wertheimer— comedyAtypical; convertthe bOdy's own cells intO Getty lmages the return Of cancer-destroying agents DiffcultPeople A ePar た 28 49 ー Novelist Tom Perrotta's The King 's L ong L egacy 行 s. Fletcher Fortyyears after Elvis Presley's 5 幻 Susanna death, the icon s rise, fall and Schrobsdorff: curb reb irth Offers a window on America your nostalgia ByJonMeacham 34 52 Questions for JeffFIake, the GOP ONTHE COVER: Photograph 妙 Senator taking aim MikeMorones— at the President M ⅲヮ Times TIME Asia is published TIME Asia (Hong (g) Limited. TIME publishes eight double issues. Each as two of 52 issues in an annualsubscription. TIME may 引 so publish cmasion 引 extra issues. ◎ 2017 Time Asia (Hong Kong) Limited. AII rights reserved. Reproduction in whOIe orin 代 wi 山 0 破 written is prohibited. TIME and the Red Border Design are protected through trademark regstration in the U. S. and in the countries where TIME maganne circulates. Member, Audit Bureau of Circulations. SutBcri : げ the postal services 引 e 代 us that your maganne is undeliverable, 、肥 have no ん代 he 「 obllgatlon unless 、肥 receive a corrected address within two a 「 s. CUSTOMER SERVICE AND 24 / 7 Ⅳ 0 , 砒 n more 面 ers 曲 , ツわ / W 物 w. ne おーリ .8 れ 1 / ′ⅵ *. p. You may 引 SO email ourCustomer Center at ⅵ′ 3n1- れ” 1 0 「 call ( 852 ) 312 & 5688 orwrite to Time Asia (Hong Kong) Lim1ted, 3 〃「 0 対 ord House, TaikOO PIace, 979 Kings Road,QuarryBay, Hong Kong.In 」 apan,these are 日岬ⅵ网apaれ@dme圏ね.00n10r0120666236 ( 阡 ee Dial) 0r2-51-27FA ね go , Minat&ku,Tokyo 1056227. Ad 冊臧 : Forinformation and rates, HongKongTelephone: ( 852 ) 312 & 5169. Orvisit: せ tn れ 0.8n1 / れ 1 ね k 忙 . Reprint: lnformation is 訓 ab 厄 at ゼ宿冶.com/せme/repけれ区 To requestcustom reprints.visitdmereprine.com/ Mailinglist: 、阨 make a ⅲ on ofourmailing listavailableto reputablefirms. 『 u would prefer that を not include your name, please ou 「 Customer Services Center. TIME Asia is edited in Hong Kong and printed in Singapore and Hong Kong. SingagX)re MCI (P) NO. 06 〃 08 / 2017. Malaysia KKDN gErmit no. PPS 676 / 03 / 2013 ( 022933 ). ldeas, opinion, innovations The Brief ユ引 A total solar News from the し S. and eclipse could around the Ⅳ 0 月 d provide unity for a 5 ー Tensions with divlded nation North Korea near a Ⅱ boil ユ引 The power of microgrids : 7 ー A controversial why small-scale proposal for the energy grids are U,S. strategy in increasingly Afghanistan popular 8 llan Bremmer 19 ー New research 0 Ⅱ grades Secretary Of bird brains reve als State Rex Tillerson clues about the innerworkings Of 9 ー Facts vs. human brains alternative facts 2 例 Greening 10 ー An insurgency China's Kubuqi stirs inVenezuela Desert 1

Reviews Time 0 ーをミ、 mother and student whO put her education on h01d tO organize marche S and demonstrations in the wake of Brown's killing. Her daughter Kenna was 6 at the time and tOOk part in the protests with her mother from the start. "I want her tO think for herself, to resist and p articip ate in de mocracy, Farrell says. "That is your right, and that c annot be taken away from you. The most effective images n Whose Streets? are those 0f peaceful protesters holding s igns ー including two girls be aring matching placards emblazoned with pink handprints and the legend DON'T SHOOT— as members oflocal law enforcement and the military hold their weapons at the ready. ()t times during the demonstrations, police used tear gas. ) ln one sequence, police tell nighttime demonstrators tO “ return tO their homes; unaware—and seeming not tO care—that those people are standing ⅲ their own front yards. F01ayan also includes footage ofthe looting and rioting that are part Of this story, an eruption Of anger 'lt wasn't being and frustration that marred registered ⅲ the p rote sts that ought tO have been peaceful. But the movie mainstream media isn't intended tO be a strict as grie f— it was procedural record 0fwh0 being registered as did what, when. lnstead, "They're thugs. "' it's a brash example 0f SABAAH FOLAYAN, in E 〃 e, guerrilla filmmaking— its describing the frustration immediacy and itS energy that led her to make are its stronge st attributes. Whose Streets?, about the Ferguson protests The protests gave a jolt of momentum tO the Black Lives Matter movement, established ⅲ 2013 following the acquittal 0fGeorge Zimmerman ⅲ the killing ofTrayvon Martin. Whose Streets? is part of the middle ofthe story. lt's by no means the end. 0 ドⅧ 0 BLAC K IIVES T を : 丁こ、 、デ第ド MOVIES Activist Brittany Farrell and daughter Ke れれ 0 : these are their streets Whose Streets? is a ragged, bracing protest document By Stephanie Zacharek LITTLE GOOD CAN COME FROM THE TRAGEDY OF MICHAEL Brown. The 18-year-01d unarmed black manwas shot to death in the city ofFerguson, MO. , near St. Louis, on Aug. 9 , 2014 , by white police offlcer Darren Wilson, who fired 12 bullets. After Brown was killed, his body lay ⅲ the street for four hours before being transported tO a morgue. A St. Louis County grandjury declined t0 indict Wilson, and a subsequent Department ofJustice investigation concluded that he did not ViOlate Brown's constitutional rights. But the community knew that a grave wrong had been committed. Citizens gathered in peaceful protest, though in some cases their anger erupted into violence. Sabaah Folayan's documentary Whose Streets?, co-directed by Damon Davis, is a gritty record ofthat time and its aftermath. lt repre sents the spirit Of something more powerful than a bullet, the seed ofsomething good springing from a terrible and unjust event. Whose Streets? is rough around the edges, like a torn photograph whose borders have also been raggedly burned. But that's more a strength than a liability: Folayan makes extensive use Of citizens' cell-phone and video-camera f00tage shot on the fly, much 0f it capturing a community struck with anger and s orrowful shock in the hours and days following the shooting. Folayan als 0 conducts interviews with the people who formed the backbone of the resistance movement that sprang up in Ferguson and quickly captured the attention 0f the country, and 0f the wo rld. Those interviewees include Brittany Farrell, a young 46 TIME August 21 , 2017 ロ

0 0 Presley autographing phOtOS in Houston ⅲ 1956 0 0 3 ◆ 82.6 % Rating Of PresIey's first appearance on The Ed Su 〃 ivan Show, on Sept. 9 , 1956. He later played on the program tWO more times. He was paid $ 50 , 000 for the shows, a huge sum atthattime. ⅲ 1956. "I just fell into it, really. My daddy and I maestro ofSun Records whO recorded artists such as were laughing about it the other day. He looked at B. B. King and lke Turner in a still-segregated South, me and said, 'What h 叩 pened, E? The last thing I understood the underlying realities 0f Jim Crow can remember iS I was working in a can factory and America. Chuck Berry and Little Richard would be you were drivin' a truck' ... lt Just caught us up. early breakout stars across the color line, but Phillips believed that would not be enough to integrate the Ⅱ . THESURGE cultural and commercial markets. "I knew that for Presley emerged at the moment the machinery 0f black music to come to its rightful place in this post—World War Ⅱ mass culture began t0 hum. The country, we had tO have some White singers come world was on the move; 01d barriers were under over and dO black music—not copy it, not change, siege; new possibilities were opening up. lt was the not sweeten it. Just dO it," he said. With presley's age 0f the GI Bill and Brown v. Board 0fEducation, emergence ()s well as Bill Haley's and Jerry Lee suburbs and television, interstate highways and Lewis', among others), Phillips' prophecy came true, fast fOOd. Material prosperity in Eisenhower's but not without resentment from the architects Of America was startling. Families whose forebears the tradition Presley was drawing on. "I was making had struggled on the fringes of farming and of everybody rich, and I was poor; ” said Crudup, wh0 debilitating manufacturing work suddenly had originally recorded "That's AII Right. " "I was born more money (and more things, ranging from TVS tO poor, I live poor, and l'm going t0 die poor. ” washing machine s ) than they could have imagined ln the white mainstream, Presley's story was two decades before, in the depths Of an economic quinte S sentially American— a striver rising tO riches crash that seemed to go on forever. When J0hn from largely impoverished obscurity (his family Maynard Keynes was asked whether there had lived ⅲ a federal housing project ⅲ Memphis after ever been anything like the Great Depression, he moving tO Tennessee) on the strength Of his talent, had replied, "Yes. lt was called the Dark Ages, and not on the circumstances Ofhis birth. "I don't know it lasted 400 years. ” One unexpected benefit from what it is; ” Presley told the Saturday Evening Post THE ONCE AND FUTURE KING PresIey makes one Of his 升 t public performances, at the Mississippi-AIabama Fair and Dairy ShOW. His song earns him a fifth-place prize, and months ね t he begins playing guitar. EIvis PresIey is born in TupeIO, Miss. tO GIadys and Vernon く PresIey Signs with RCA in a deal worth S40 , 000. The PresIey family moves tO Memphis. PresIey soon becomes interested in the 0 blues scene. PresIey. 》 NOV. 1955 NOV. 1948 OCT. 3 , 1945 JAN. 8 , 1935

and the Gulf Co ast. ) Hi s father struggled to eke out a living, working different jobs and signing up for FDR's Works Progress Administration after doing time at Mississippi's Parchman prison for forging a check. His mother was devoted to her son, all the more SO because Presley had had a twin brother whO was stillborn. Presley grew up as a member 0f the Assembly of G0d, a denomination that emphasized personal religious experiences. MusiC and singing were essential means Of creating ecstatic moments Of transcendence: a vibrant, emotional, very public form of faith. The individual was the vessel of the H01y Spirit—a performer, ifonly for the congregation. Eventually the family moved to Memphis, which was perfect for Presley. A longtime cotton hub, the city, like PresIey himself, sat between the blues- soaked Delta and the virtually all -white country-and- western music world ofNashville. ln the summer of 1954 , after a brief, not-quite-successful visit the year before, Presley cut a record with the producer Sam PhiIIips, who ran Sun Records on Union Avenue. A few weeks later, at an open-air performance at Overton Park Shell in Memphis, Presley played the two songs from that recording. As Joel Williamson, a scholar 0fSouthern history, observed, Presley took "That's AII Right ” (written by an African-American blues musician, Arthur Crudup) and "Blue Moon Of Kentucky' (written by a white bluegrass man, Bill Monroe) and made them his own. "Elvis, using his God-given rich and versatile VOice, perfected by practice, gave [the songs] a different turn,' Williamson wrote. "Just as 'That's All Right' was not black anymore, 'Blue Moon' was no longer hillbilly; it was joyous, country-come-to-town and damn glad t0 be there. ” The audience, led by ecstatic young women, went wild. "l was scared stiff; ” Presley recalled. "Everyone was hollering, and I didn't know what they were hollering at. ” That much, at least, should have been clear: they were hollering at him, transported by his electric physicality and extraordinary voice, which ranged comfortably from baritone tO tenor and above. He did not simply sing; he became the music, as though possessed by a spirit ofjoy and release back at the Assembly of G0d. lt was sexual, yes, and thus disturbing t0 the more placid and puritanical observers, but it was inescapably religious tOO, in the sense that religion evokes realities ordinarily hidden movies, in hiS private worlds at Graceland and in from the human eye. Here, on a covered stage in a Las Vegas, Presleywas a forerunner 0fthe reality-TV era in which celebrities play an outsize role in the park in western Tennessee, a white man was drawing on the deep tradition 0fAfrican-American blues. ln imaginative lives oftheir fans. Before Diana, before the popular mind, a fresh genre—a different epoch— MichaeI, before Kim, before Trump, there was Elvis. was emerging. 'Before Elvis,"J0hn Lennon is said tO have remarked, "there was nothing. ” That was not strictly true. presley was a vehicle— presleywas born in Tupe10, Miss. , ⅲ 1935 in the hilly cultural critics would say he was basically a mimic, upcountry region Of the state that the writer Julia or even a thief—of the black musical and spiritual Reed has described as the BaIkans ofthe South. (The experiences Of his native Mississippi. Phillips, the other two distinct Mississippi worlds are the Delta PREVIOUS PAGES: MPTV; THESE PAGES: RCA, PROFILE, STAGE: ALFRED WERTHEIMER—GETTY IMAGES ( 3 ) : CLOSEUP: MPTV 1 B Estimated number Of units Presley's music has SO 旧 , making him the most commercially successful S60 music artist Of alltime I.RISINGSUN 37

PICKS BOOKS lt's not ove r ye t September's comingsoon. Here are three beach-vacation clas- sics fO 「 the precious last weeks ofsummer. —Sarah Begley Everyday people, extraordinary b00 s TOM PERROTTA HAS DOCUMENTED DECADES' WORTH OF social issues in deceptively domestic novels. He addressed modern parenting ⅲ 2004 ' s 田 e Children, the Christian right ⅲ 2007 ' s The Abstinence Teacher and the response tO grief in 2011 ' s The Leftovers. AII those works take place in suburban America and have at their centers workaday folks living against the b ackdrop Of sweeping change. ln examining the national intere st by way Of dinner-table conversation, perrotta has created some of the most memorably human drama ofhis era. His new novel, Mrs. Fletcher, about a mother and son, is the latest example. "I never feel like l'm writing about the suburbs,: ” says perrotta. "I feel like l'm writing about people wh0 live in the suburbs, and people are a subject Of inexhaustible interest. ” Mrs. Fletcher is a look at two kinds Of sexual revolution: the breakdown ofbarriers created by lnternet porn and the new manner oftalking about sex on campus. lt will spark plenty 0f conversations before college drop-offbegins ⅲ August ・ TO Perrotta, lnternet porn—the sort that comes tO Obsess empty-nester Eve Fletcher—has been a democratizing force: "I certainly don't want t0 be the person defending porn, but one of the things it's done is show that real people are not as sexually picky as American commercial culture might lead us tO believe. There's a place in porn for older people, people 0f different races. ” Meanwhile, new cultural wokeness—and rigidity— creates confusion and resentment for Brendan, Eve's blithely self-assured, unsophisticated son. Perrotta demonstrates hO 、 the conversation around re-envisioning sex and gender, one that occurs entirely above Brendan's head, has consequences. ln the author's telling, it "leads tO a kind ofpuritanical calling-out ofpeople wh0 have sinned against these goals. ” This may be the latest Of perrotta's works tO be adapted by Hollywood. HBO, which broadcast the grand-scale ad 叩 tation The Leftovers, has optioned Mrs. Fletcher, following film versions of Perrotta novels Election and Little Children. But the in- demand author's wading intO the contemporary campus comes from a prosaic place: chats with his college-age children, wh0 also helped inspire his previous b00ks. (LittIe ChiIdren came out when they were just that. ) The parent and his children have had very different experiences. "1100ked at college as this place 0f freedom and liberation and ん n , ” says perrotta (Yale ' 83 ). "And now a 10t 0f people experience it as a kind 0f minefield, where you have t0 watch what you say. Maybe that's not a bad thing, but I think the sense Of it as a fun place or a place where the world gets bigger has become much more complicated. " perceptive 0f slight shifts in the SOCial current but never condemning hiS sinning characters' souls, perrotta proves an amiable guide through it all. —D. D. Tom Perr tta F SCOTT FITZGERALD T E N D E 」 5 TENDER THE NIGHT ( 1934 ) By F. Scott 日 ge ′ a Acouple'stenuous marriage begins tO unravel on the French Riviera, surrounded by temptation and danger. lnspired in partbyhis own life, it was thelast novel Fitzgerald would complete. Flctehcr COMPLEX CHARACTER NewIy liberated Eve is the latest memorable Perrotta heroine. Says the author: "l'm really interested in tellingthe story Of women Of my generation. " PHILISTINES AT THE HEDGEROW ( 1998 ) By Steven Gaines The journalist's pop history examines passion and property in the Hamptons," where the rich and the famous behave badly and compete over real estate with long-entrenched locals. MeM 計一 0 齢 HOW STELLA GOT HER GROOVE BACK ( 1996 ) By Terry McMiIIan A divorced investment analysttakes a break from her life as a single mom and heads on vacation tO 」 amaica, where shefalls fora man halfherage. 49

LightBox Court inJune, hailed the uprising in a filmed interview from his hiding place. Hacked government websites urged citizens tO "unite with military units and police who declare rebellion. " The streets Of Caracas were relatively quiet following the assault, with residents queuing for hours t0 feed their fami- lies, but some did applaud the idea ofan army uprising. “ The military is the only hope; ” s aid Luis Garmendia, a shop- keeper in the city center. But there was also speculation that the raid was a ruse by the government tO divert attention from itS economic disaster. Despite sitting 0 Ⅱ the largest 0i1 reserves on the planet, Maduro has steered the economy intO hyperinfla- tion that has le 仕 millions hungry and poor. He has long blamed mysterious right-wing subversives for the mess, and he did so again on Aug. 6 when he called the raid "a terrorist attack ” by mercenaries financed in Colombia and the U. S. , linking it to the long history of gringo intervention the region. The chaotic situation in Vene zuela makes it tough t0 predict whether the threat Ofa coup is real or whether Maduro and his allies will be able to cling tO power for years. But there is fear an armed struggle could lead to CiVil war. “ The scenarios Of violence are something the government is pushing for by closing the channels for dialogue,: ” Juan Requesens, an opposition lawmaker and former student leader, tells TIME. “ They are pushing toward confrontation, but it will be an unequal one. They have the arms. We don't. ” That makes the army's loyalties a matter Of intense speculation. Chåvez, a paratrooper WhO launched his own failed coup in 1992 , put offcers into his government and gave Others expropri- ated land to win their loyalty. He also installed a Cuban-styIe system to watch for any dissent ⅲ the ranks, says pedro Pedrosa, 4 political consultant and for- mer Venezuelan naval Off. cer. Yet under the surface, Pedrosa says, many soldiers are getting angrier, especially as they repress f00d riots ⅲ their own neighborhoods. "lnside the military, there is much, much discontent," he says. "ln the end, it could explode. ”—WITH REPORTING BY JORGE BENEZRA/CARACAS 12 TIME August 21 , 2017 0 0 0 0 0 A ツ ou 市 h01ds 0 M010tov coc た地ⅲ eastern Caracas A dried-up 和 u れ ta ⅲ砒 plaza 0 pos ⅲ 0 れ厄 ader 0 Borges claims voterfraud onAug. 2

immune cells turned out tO be more Of a hit-or-miss endeavor than a reliable road tO rem1SSion. After spending nearly three decades on the problem, June zeroed in 0 Ⅱ a malignant fingerprint that could be exploited tO stack the deck Of a cancer patient's immune system with the right destructive cells tO destroy the cancer. ln the case Of leukemias, that marker turned out t0 be CD19, a protein that all cancerous blOOd cells sprout on their surface. June repurposed immune cells tO carry a protein that would stick tO CD19, along with another marker that would activate the immune cells tO start attacking the cancer more aggressively once they found their malignant marks. Using a design initially developed by researchers at St. Jude Children's Research Hospital for such a combination, June and his colleague Bruce Levine perfected a way to genetically modify and grow thes e cancer-fighting cells ⅲ abundance in the lab and to test them ⅲ animals with leukemia. The resulting immune platoon of CAR T cells is uniquely equipped to ferret out and destroy cancer cells. But getting them intO patients is a complex process. Doctors first remove a patient's immune cells from the blood, genetically tweak them in the lab to carry June's cancer-targeting combination and then infuse the modified cells back into the patient using an IV. Because these repurposed immune cells continue tO survive and divide, the therapy continues tO work for months, years and, doctors hope, perhaps a life- time. Similar tO the way vaccines prompt the body to produce immune cells that can provide lifelong protection against viruses and bacteria, CAR T cell therapy could be a way tO immunize agamst can- cer. "The word vaccination would not be inappropriate; ” says Dr. Otis Brawley, chief medical offcer of the American Cancer Society. June's therapy worked surprisingly well in mice, shrinking tumors and, in some cases, eliminating them altogether. He 叩 plied for a grant at the National Cancer lnstitute at the National lnstitutes of Health to study the therapy in people from 2010 tO 2011. But the idea was still SO new that many scientists believed that testing it ⅲ people was t00 risky ln 1999 , a teenager died days after receivlng an 32 TIME August 21 , 2017 experimental dose ofgenes tO correct an inherited disorder, and anything involving gene therapy was viewed suspiciously. WhiIe such deaths aren't entirely unusual ⅲ experimental studies, there were ethical questions about whether the teenager and his family were adequately informed of the risks and concerns that the doctor ⅲ charge of the study had a financial conflict Of interest in seeing the therapy develop. 0 伍 c s ⅲ charge ofthe program acknowledged that important questions were raised by the trial and said theytook the questions and concerns very seriously. But the entire gene-therapy programwas shut down. AII of that occurred at the University Of pennsylvania—where June was. His grant application was rejected. lt would take two more years before private funders—the Leukemia and Lymphoma Society and an alumnus ofthe umversity WhO was eager tO support Ⅱ e 、 cancer treatments—donated $ 5 million tO give June the chance t0 bring his therapy tO the first human patients. THE DATE JULY 31 has always been a milestone for Bill Ludwig, a retired cor- rections 0ffcer in NewJersey. lt's the day that he joined the Marines as an 18-year- old, and the day, 30 years later, that he married his wife Darla. lt was alSO the day he went t0 the hospital tO become the first person ever tO receive the combination gene and CAR T cell therapy, in 2010. For Ludwig, the experimental ther 叩 y was his only remaining option. Like many people with leukemia, Ludwig had been living on borrowed time for a decade, counting the days between the chemotherapy treatments that would hOld the cancer in his blood cells atbay for a time. lnevitably, like weeds in an untended garden, the leukemia cells would grow and take over his blood system again. But the periods Of reprieve were get- ting dangerously short. "I was running out oftreatments; ” says Ludwig. SO when his doctor mentioned the trial conducted by June and Porter at the University 0f Pennsylvania, he didn't hesitate. "I never thought that the clinical trial was going tO cure me,: ” he says. "I just wanted tO live and t0 continue t0 fight. lfthere was something that would put me intO the next month, still breathing, then that's what I was looking for. ” When LudW1g signed the consent form for the treatment, he wasn't even tOld what tO expect in terms Of side effects or advers e reactions. The scientists had no way 0f predicting what would happen. "They explained that I was the first and that they obviously had no case law, so t0 spealg ” he says. SO when he was hit with a severe fever, had difflculty breathing, showed signs of kidney failure and was admitted tO the intensive care unit, he as- sumed that the treatmentwasn'tworking. His condition deteriorated SO quickly and SO intensely that doctors tOld him tO call his family to his bedside, just four days after he received the modified cells. "I told my family I loved them and that I knew why they were there,: ” he says. "I had already gone and had a cemetery plot, and already paid for my funeral. ” Rather than signaling the end, Lud- wig's severe illness turned out tO be evi- dence that the immune cells he received were furiously at work, eliminating and sweeping away the huge burden 0f can- cer cells choking up his bloodstream. But his doctors did not realize it at the time. lt wasn't until the second patient, Doug Olson, who received his CAR T cells about six weeks after Ludwig, that Porter had a eureka 1 れ 0 Ⅱ lent. When he received the call that Olson was also running a high fever, having trouble breathing and showing abnormal lab results, Porter realized that these were signs that the treatment was working. "lt happens when you kill huge amounts of cancer cells all at the same time; ” Porter says. What threw him off initially is that it's rare for anything tO wipe out that much cancer in people with Ludwig's and Olson's disease. June and porter have since calculated that the T cells obliterated anywhere from 2. 引 b. to 7 lb. ofcancer in Ludwig's and Olson's bodies. "I couldn't fathom that this is why they both were so sick' ” says Porter. "But I realized this is the cells: they were working, and working rapidly. ltwas not something we see with chemotherapy or anything else we have to treat thiS cancer. ” LUDWIG HAS NO 、 been in remiSS10n for seven years, and hiS success led tO the larger study of CAR T cell therapy ⅲ children like KaitIyn, who no longer respond tO existing treatments for their cancer. The only side effect Ludwig has

QUICK TALK John C 0 加 the drama C01umbus, the acto ら 45 , s the estranged SO 可 0 れ architect wh0 has ta れ卍 . れ wasfilmed ⅲ Columbus, 加 d. , 0 mecca ofmodernist architecture. Did 亡 e movie change OW yo Ok at architecture? I thought about hOW architects can make us feel in the way they design spaces. l'm thinking about North Christian Church, by Eero Saarinen. My father was a preacher. They say the church is not the building, it's the people in it. ln this church, the seating went upward. lt was in the round, SO the congregants lOOked at one another and down at the preacher. lt was impossible not tO conclude that the church was the people around you. The film talks about seeing the place where YO grew up with new eyes. Has that happened t0 YO 設 ? L. A. 's a great place t0 have that happen. You drive by these mini-malls. They look so ugly, but ifyou close your eyes and open them, it's remarkable that so much life is happen- ing. There might be a Spanish-speaking church or a Korean karaoke room. These little mini-malls contain all this life. You're in the upcoming season Of TheExorcist. Did it give yo 収 night- mares? part Ofthe reason I tOOk [the role] is I have not been ⅲ this genre. I saw it as very white. Horror has been killing offthe blond cheerleader. But typically, it is a struggle to remember something's scary. [Filming Star Trek on] the Enterprise, you have tO work at pretending you're flying through space. I expect the same in horror. What dO yo 収 remember about the depictions Of Asian Americans onscreen When YO 収 were a kid? I remember seeing not much. And when it was there, it was usually insulting. I didn't want tO contribute tO that library 0f iconogr 叩 hy. I always saw it from the vantage point Of 12-year-old me. lfl had an audition for the role of a Chinese delivery guy, would 12-year-01d me appreciate it or be dismayed by it? Despite yourself, you believe what the screen tells you about yourself. —ELIZA BERMAN ON MY RADAR Pattinson in GOOd Time: the eyes have it SEARCH PARTY “石題 stgo 目れ tO 社 . That s れ 03 0 Ⅲ 0 名 i 9. A 0 S れ 0 々 at , the 厄 ad actress, is rea リ 9 新 ted. BO リ she 900d. ” MOVIES Pattinson packs a punch in GOOd Time IN THE EARLYMINUTES OFJOSH AND BENNY Safdie's G00d Time, we meet Nick Nikas (Benny Safdie), a sullen young man who clearly suffers from some kind ofintellectual disability, as he's being quizzed by a kindly mental-health practitioner. Nick wears a hearing aid. His words come slowly—his pillowy lips can barely form them—and his eyes seem shut offfrom the world. When the shrink asks Nick what first comes tO mind when he hears the words scissors and a cooking ” hiS answer— as easy tO read as a street sign—is, can hurt yourselfwith both. ” Nick needs real help, but he's not going to get it from his bad- apple brother Connie (R0bert Pattinson), who manipulates Nick even as he protects him. The tWO are entwined in a figurative headlock Of dependence and twisted affection. lt's a power struggle neither can bust out Of. The Safdie brothers' fourth fiction feature is partly a study ofdysfunctional brotherhood, partly a gritty-funny New York City crime caper. lfyou can tolerate the Safdies' fondness for extreme closeups—the picture is shOt largely in a mode I like t0 call Blackhead Theater—Good Time offers plenty ofsweaty suspense laced with a few bittersweet laughs. But Pattinson is the real reason tO see it: his Connie, wiry and intense, with beady, cracked- out eyes, is the kind ofguyyou'd cross the street tO avoid. But by the movie's end, you realize that his desperatlon veils a rush oflonging. For what? Pattinson plays Connie as a guy wh0 just does n't know— and that not knowing dogs him like a silent, persistent ghost. —S. z. 寸 V 】一 1 0009 2S39VVNl A ト 139 ー 30 を d ・ 3 A}NV 】 0 工 0 一くコ ON9VL•N 、 S ト 33d トの 3S0 工 M 47